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Li D, Liu X, Pi W, Zhang Y, Yu L, Xu C, et al
This led the authors to theorise that the high doses might be necessary to bypass any potential intracellular transport defects or enzymatic abnormalities
This theory also proposes that malfunction of an as yet undiscovered lactate shuttle within the NMJ may be a pathological feature of ALS, suggesting that supporting mitochondrial function may optimize lactate metabolism and combat the toxicity caused by accumulation of excess lactate
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