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Figure 2 3.1 Iron accumulation and oxidative stress Oxidative stress represents a fundamental mechanism in CHD pathogenesis and serves as a critical trigger for cellular ferroptosis

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Beyond gastrointestinal effects, clinical data and class-level evidence from licensed incretin agents (semaglutide, tirzepatide) have flagged concerns regarding: Heart rate elevation: Increases in resting heart rate are a recognised class effect of GLP-1 receptor agonists, documented in the SmPCs for semaglutide (Wegovy) and tirzepatide (Mounjaro)

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Mol Metab 11:205211

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Giblin K et al

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