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Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome

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[PMID: 1027438] PubMed record related to this compound for laboratory literature review

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It differs from the native 70 residue growth factor by an arginine-for-glutamate substitution at position 3 and a hydrophobic 13 residue N-terminal extension, MFPAMPLLSLFVN, which is itself a residual fragment of the methionyl porcine growth hormone fusion partner used to express the protein in Escherichia coli