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Elevated cortisol directly inhibits GH receptor signaling in target tissues and increases hepatic GH resistance, meaning even if you achieve a GH pulse, downstream IGF-1 production and metabolic signaling are impaired
Nakamura A., Sakai K., Takahashi Y., Shiomi H
Additionally, other factors such as having had gastric bypass surgery or taking antacids long-term can lead to deficiency
This latter benefit may make it possible to more adequately treat psychiatric conditions, which are notoriously difficult to treat, in part because patients often discontinue their medications secondary to severe side effects
The authors concluded that high-dose curcumin supplementation effectively reduces oxidative stress and inflammation in postmenopausal women [64]
DOI: 10.1038/s41467-018-07019-x
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