The evolutionary origin of exendin genes ( exendin 14) has not been fully resolved but it seems likely that exendins evolved by duplication from a glucagon-like peptide gene precursor 14
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Once-weekly trelagliptin versus daily alogliptin in Japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study
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1 Introduction The idea that substances produced by duodenal mucosa could stimulate and initiate pancreatic endocrine, thereby reducing the amount of urinary glucose in patients with diabetes, was first proposed in 1906 (Moore, 1906)