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ETI, West Sussex, UK) by inserting a corn oil-soaked flexible bead probe into the rectum after the intraperitoneal administration of 200 L of vehicle, exendin 939 (50 g/kg), or BCTC 5 mg/kg in wild-type mice ( n = 6)

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Acknowledgements This work was supported by Ministero dellIstruzione, dellUniversit e della Ricerca of Italy, Progetto PONRicerca e Competitivit 20072013PON01_01802: Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redoxsensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e loro delivery mediante piattaforme nano tecnologiche, and PON01_02512: Ricerca e sviluppo di bioregolatori attivi sui meccanismi epigenetici dei processi infiammatori nelle malattie croniche e degenerative

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Consultation with the FDA resulted in a reduction in the studys sample size from 600 to 292 patients based on the measured pooled incidence of the primary endpoint and a re-estimation of the study power

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