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Accepted 17 March 2022

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Scientific References Sikiric P, et al

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On the one hand, Stefater and colleagues showed that, during development, the stimulation of non-canonical Wnt-signaling (Wnt11 and Wnt5A) induced retinal CD11b + F4/80 + macrophages to secrete soluble VEGFR1, sequestering VEGF from the surrounding environment and thus reducing its availability for endothelial cells (53)

While a shortage of vitamin B6 will limit these functions, supplements of this vitamin do not enhance them in well-nourished individuals