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Courtois, R

Cyanocobalamin Drugs (BNF/NICE)

[4] Where published studies do not report a toxicological signal, the correct interpretation is not reported under the tested experimental conditions, not fully excluded. This distinction is important because many published studies involving 5-Amino-1MQ were designed primarily to evaluate NNMT-related biological mechanisms or model-specific metabolic endpoints, rather than to serve as dedicated toxicology programs

Pregnant or breastfeeding individuals, as well as those with certain medical conditions, should consult with their healthcare provider before considering B12 injections

This is a clinical decision rather than a reason to describe injections as generally superior

When administered by a licensed medical practitioner , B12 injections are considered safe and effective