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None of these effects require a functioning beta cell which is exactly why researchers started exploring them in T1D
Some effects improve as the body adjusts, while others may persist or interfere with daily life
Front Immunol (2020) 11:576818
In the phase 2 study published in the New England Journal of Medicine, gastrointestinal symptom rates nearly doubled when participants jumped directly to 8mg instead of titrating gradually from 1mg
At the same time, Trim37 deficiency increased global chromatin accessibility, with 27,919 upregulated peaks compared with 5215 downregulated peaks, particularly in regions associated with developmental genes (Fig
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