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Jumper, J

However, maintaining consistent levels in the body may support long-term effectiveness

Phase IV clinical trial BLOSSOM proved that both pregabalin and duloxetine are effective medications for treating pain in DPN in more than 86% (173/201) of randomised patients [90]

COMT is involved in converting 2-hydroxyestradiol (an antiestrogen) to 2-methoxyestradiol (proestrogen), creating a hyper-estrogenic milieu due to the decrease in antiestrogen and an increase in proestrogen

Kalmar et al., 2008