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*Correspondence: Yi Hua, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Consequently, disruptions in GSH biosynthesis, utilization, or recycling are hallmarks of oxidative stress and have been implicated in the pathogenesis of aging, neurodegenerative diseases like Parkinsons and Alzheimers, cancer, and various metabolic disorders [37]
27 Under hypoxic conditions, intervened by hypoxia-inducible factor (HIF), there is a reduction in hepcidin expression, which promotes iron release