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Phase I and II clinical trials conducted have shown improved cognitive and motor function with different drugs from GLP-1RA group although the small sized and limited duration of trials have not provided a conclusive result to influence the practice, although with further advancement in ongoing trials effects observed may be noteworthy for intervention in future practice (119)

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doi: 10.1038/ijo.2013.149 62 BlundellJFinlaysonGAxelsenMFlintAGibbonsCKvistTet al

Also, there might be a link between insulin resistance and RA disease activity

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However, this hormone is rapidly broken down by the enzyme DPP-4, lasting only minutes in circulation