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This has led researchers to explore alternative delivery routes that maximize cellular uptake, stability, and systemic reach, while minimizing degradation
The ascorbate peroxidase-glutathione reductase (APX-GR) system is far efficient in detoxification of hydrogen peroxide (H 2 O 2 ) than catalase (CAT) and peroxidase (POD) and the exogenous addition of ascorbate through the nutritional solution was reported to result in marked reduction in the activities of both enzymes (Dolatabadian and Jouneghani, 2009)
This detoxification mechanism has made GSH a critical compound in hepatocyte and toxicology research models
Three studies assessed the effectiveness and safety of acetyl-l-carnitine in diabetic neuropathy [64,65,66] (Table 2)
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Pharmacol Gupta GL, Rana AC (2007) Protective effect of Withania somnifera Dunal root extract against prooxidant activity of lead in mice brain
