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coli suppresses postprandial blood glucose or appetite in the host may be the result of interactions between the host and the gut microbiota 14, 15
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Key tips for clinicians include: Ask about gallbladder history before starting therapy Monitor for right upper quadrant pain or nausea after meals Educate patients on when to seek medical evaluation For most, the benefits of GLP1 therapy outweigh the risks, but patient awareness is critical for timely diagnosis and care
However, long-term risks such as rare adverse effects, metabolic effects over years, effects on bone, gallbladder, and pancreas need phase-3 trials and post-marketing surveillance to ensure the medication is safe for long-term use
