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This is the dual-agonist component that tirzepatide shares with retatrutide

This suggests a very good safety and tolerability profile indistinguishable from placebo in those trial settings

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(2001, Int J Obes) showed that chronic treatment with AOD-9604 restored repressed beta-3 AR mRNA levels in obese mice toward lean-mouse values, characterizing a chronic-treatment mechanism that complements the fragment's acute lipolytic action