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Hydrogen peroxide and iron ions can modulate lipid peroxidation, apoptosis, and the cell cycle, but do not have a significant effect on DNA double-strand break

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15 Likewise, secreted factors such as LGALS13 may enhance the susceptibility of neighboring tumor cells to ferroptosis-based treatments by lowering their antioxidant threshold, 24 intentionally harnessing ferroptotic contagion as a therapeutic amplifier

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