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# Claims pending evaluation by EFSA

Now, let's address the elephant in the room: side effects

High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy

A deficiency in Vitamin B12 can lead to fatigue, weakness, and even neurological complications

Int J Mol Sci (2020) 21(17):6206

If you suffer from chronic fatigue, nutrient deficiencies, or need quick hydration, IV therapy may be beneficial