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The oxidative stress caused by a decrease in GSH levels can then impact microglia function and potentially lead to a more pro-inflammatory M1 phenotype that has reduced -amyloid clearance capabilities (Vilhardt et al., 2017)

Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy

Autophagy 12 , 14251428 (2016)

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Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility

or have a job that keeps you running around and in the heat all the time