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This structural modification significantly reduces binding to IGF-binding proteins (IGFBPs) , resulting in rapid, localized IGF-1 receptor activation in research settings

The diagnosis of dementia was made according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.17 Only persons with a duration of symptoms longer than 6 months and a score for severity of dementia of 1 or higher on the Clinical Dementia Rating Scale were considered incident cases.18 Patients with suspected cognitive deficits for whom definite dementia could not be established underwent annual reassessment

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Conditioned media was collected from the PC cultures in the second day after the seedings and mixed in a 1:1 ratio with the medium of hEC [24]

10.1016/S1569-1993(03)00097-3 40