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TRIUMPH-1 reported continued loss in a prespecified extension for participants with baseline BMI of at least 35, but maintenance after discontinuation, long-term adverse events, and real-world adherence remain open questions [7]
Rare but serious adverse effects include pancreatitis, gallbladder disease, hypersensitivity reactions (including anaphylaxis and angioedema), and, for Wegovy specifically, suicidal ideation
10.1080/10717544.2016.1233589 44 HuC.-M
The GIP (glucose-dependent insulinotropic polypeptide) receptor component enhances insulin secretion and may contribute to fat metabolism through direct effects on adipose tissue
This stimulation is associated with improved circulation and mitochondrial efficiency, supporting cellular energy utilization
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