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For example, recent studies have shown that perturbation of COQ2, a key enzyme responsible for coupling the isoprenoid tail to the quinone head group, increases ferroptosis sensitivity, and thus targeting COQ2 enhances ferroptotic vulnerability in multiple myeloma cells 35

Further translational research and prospective clinical trials are required to clarify causality, determine effect size, and identify high-risk groups most likely to benefit

Investigational doses range from 250mcg to 2mg administered subcutaneously daily or every other day, with side effect incidence increasing at higher doses