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GHK-Cu is the copper(II) complex of glycyl-L-histidyl-L-lysine (Gly-His-Lys), a tripeptide first isolated from human serum albumin in 1973 whose concentration declines with age

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This copper-binding motif is critical: the apo-peptide (GHK without copper) shows substantially reduced biological activity in most in vitro assays, indicating that the metal center is required for receptor interaction and downstream signaling

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