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Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use Zepbound

It is possible that increased ATP synthesis due to influx of KB or MCFAs in the brain results in elevated extracellular adenosine concentrations, which act upon AR (105, 113), although the exact mechanism is unknown

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1 Researchers acknowledged the genetic effect on weight loss was relatively small but said the findings lay the foundation for precision medicine approaches to obesity treatment by providing direct evidence that variation in drug-target genes contributes to differences in how patients respond

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