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The blockbuster weight loss medications that have transformed conversations about obesity and metabolic healthsemaglutide (Ozempic and Wegovy), tirzepatide (Zepbound or Mounjaro), and retatrutide (a newcomer on the block thats not yet FDA approved but highly anticipated for approval next year)are all peptide-based drugs
This historical trajectory strongly suggests that GLP-1 should not be viewed as an isolated success, but rather as a prototype for a much larger class of peptidereceptor systems whose translational potential remains unrealized
Gundry RL, Fu Q, Jelinek CA, Van Eyk JE, Cotter RJ
Neurotherapeutics 18 (2), 962978
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