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For most healthy adults, the difference is minimal, because both forms restore B12 levels effectively

A key study published in the Journal of Clinical Endocrinology and Metabolism enrolled 118 GH-deficient adults and demonstrated a 30-40% increase in serum IGF-1 over 6 months of nightly subcutaneous dosing

Long-acting formulations Exploring even longer-acting versions that might enable bi-weekly or monthly administration

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Some apparent improvements were weak or affected by inadequate control groups