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Similarly, the protective effects of metformin on subchondral bone are indirect, occuring through cartilage integrity preservation and oxidative stress reduction 54

Incorporate meditation, yoga, or breathing exercises to keep stress in check

The NADPH/NADP+ ratio is regulated by nutritional state, exercise, diet, and circadian rhythms (Bradshaw, 2019

For example, it was found that Nrf2 activator diethyl maleate induced genes with antioxidant and detoxifying effects but simultaneously repressed various genes, such as those containing Nrf2-MafG or Nrf2 binding sites (25)

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