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The observed upregulation of not only the ThDP-dependent dehydrogenases limiting and feeding the TCA cycle, but also the thiamine transporters and ThDP-producing enzyme TPK1 (Figures 4B, 5B), may compensate for decreased levels and/or increased demands of thiamine in enterocytes 69 months after gastric bypass, facilitated by the higher expression of the proteins binding thiamine or ThDP
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First, the microbiota alters rapidly when exposed to great and fast changes in diet
20 Left untreated, obstructive sleep apnea has been linked to the development of type 2 diabetes, cardiovascular disease and depression
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