For the chronic dosing studies, most studies are looking at doses of 4 g/day.[ref] (This used to be the maximum recommended acetaminophen dose per day, but that has now changed to 3g/day.) For reference, a single over-the-counter Extra Strength Tylenol is 500 mg, with the directions saying not to exceed 6 tablets in 24 hours (so 3g/day)
Effect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin level in old rats
As mentioned, their primary drawback is low bioavailability
In research settings, lyophilized peptides are reconstituted with bacteriostatic water before use
MIC+B12 Methionine The essential amino acid works as a deactivating agent
So, your body ends up suffering from a lack of it, and many of the signs are similar to the general signs of aging