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GLP-1 agonists may: Optimize high-risk patients before surgery Improve metabolic control Potentially reduce surgical risk But durable long-term outcomes in severe obesity still rely heavily on: Surgical intervention Lifelong follow-up Nutritional monitoring Multidisciplinary care The future may not be medicine vs surgery. It may be the intelligent integration of both

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Those concerns are far from niche

GLP-1 receptors are expressed on immune cells, potentially reducing pro-inflammatory cytokines

The primary glucose-lowering effect of metformin resides in the gut, not the circulation: results from short-term pharmacokinetic and 12-week dose-ranging studies

Elizabeth Glowacki, an assistant teaching professor at Northeastern University, who focuses on health communication, message design, persuasion and mobile health, echoes much of that criticism