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Discussion In this study, we have identified how single amino acid substitutions to exendin-4 can dramatically enhance insulin secretion via modulation of GLP-1R binding kinetics, biased signaling, and trafficking

A retrospective analysis of more than 110,000 women between the ages of 45 and 80 found that those who took GLP-1 medications were about 30 percent less likely to develop breast cancer than those who did not take GLP-1 medications, according to research presented today at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting (Abstract 10506) by Elizabeth McDonald, MD, PhD, a professor of Radiology in the University of Pennsylvania Perelman School of Medicine and a practicing breast radiologist at Penns Abramson Cancer Center

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"The studies being presented at this year's meeting highlight how essential carefully designed trials are for evaluating new therapies, refining existing approaches, and ensuring that advances in science translate into safer, more effective care for people living with diabetes." Authors, Disclosures, and Funding In addition to Aroda, the study authors include Melanie J Davies, Jill Maaske, Marcus Millegrd, Vctor Lpez Juan, Jens Aberle, Andreea Ciudin, Rory J McCrimmon, Olof Eklund, Judy L Shih, Mikaela Sjostrand, Donna Zarzuela, and Julio Rosenstock