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Shazel Gharbi and Dr
The evidence supporting their effectiveness is strong, and their mechanisms are well-understood
Williams reported that while central blockade of the GLP-1 system with ICV administration of exendin 939 blocked the actions of central but not peripheral GLP-1, peripheral (intraperitoneal) exendin 939 blocked the appetite-suppressing actions of peripheral, but not central GLP-1, indicating that the two systems do not depend on each other for activity
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Now the situation is changing
By performing microarray gene expression analysis in -cells isolated from 60-week-old mice, we found that MOTS-c downregulates genes related to mTOR pathway ( Cd38 , Camk2a , Map2k6 , Gck , and Ulk4 ) 71,93,94,95 and serine/threonine protein kinase ( Ripk1 , Styx , Wnk1 , Mapkapk3 and Ptk2b ), which regulates protein phosphorylation (Fig
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