This was unexpected as a high GSH level from selection of phenotypically high GSH producers in the pGSH1-URA3 strain population should inhibit the expression of Ura3-GFP when under control of the GSH-regulated pGSH1
This inhibition presents itself with a reduction in hyperpigmentation and dark spots and overall skin lightening
Acknowledgements We thank Prof Wangsen Cao for their critical review and thoughtful discussion of the manuscript
Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery
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Mzire, M., Marchand, P., Larvor, F., Baza, E., Le Bizec, B., Dervilly, G., & Cariou, R