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GLP-1 receptor agonist added to insulin versus basal-plus or basal-bolus insulin therapy in type 2 diabetes: A systematic review and meta-analysis

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IGF-1 and its analogs have been central to studies examining cellular proliferation, communication, and signaling mechanisms

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While prevention is paramount, this growing mechanistic framework raises hypotheses for future studies that targeting mitochondrial metabolism can open windows of epigenetic plasticity toward more positive health outcomes, particularly in subjects with a history of adverse childhood experiences