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M.LalanneG.WangY.et al (2008)
Borenstein M, Hedges LV, Higgins JP, Rothstein HR
American Journal of Clinical Nutrition, 2006
Eli Lillys orforglipron represents a breakthrough in this transition as the first oral small-molecule GLP-1RA to complete Phase 3 trials
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Indeed, pioglitazone-induced heart failure (HF) and the withdrawal of rosiglitazone because of cardiovascular concerns eventually led to a change in the policy of regulatory authorities.9,10 The US Food and Drug Administration and the European Medicines Agency now require all new antidiabetic drugs to undergo large cardiovascular outcome trials (CVOTs) to confirm cardiovascular safety and benefits
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