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Many medications are often prescribed off-label for conditions that exceed their original FDA approval
In BARI-STEP, participants with T2D on semaglutide 2.4 mg had comparable %WL to participants without T2D, despite the number of participants with T2D in this trial being low
The lawsuits allege that the drug, which mimics the GLP-1 hormone in the body that aids in insulin secretion, causes severe side effects, including gastroparesis and pancreatic cancer
What Clinical Trials Show In large obesity trials: Average weight loss is ~15% of starting body weight with semaglutide 2.4 mg Average weight loss is ~2022% of starting body weight with tirzepatide 15 mg The majority of weight loss occurs within the first year of treatment Plateaus are common after significant weight reduction Some people lose more, some less but a flattening of the weight-loss curve is expected , especially after meaningful progress has already occurred
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