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Interestingly, while BPC-157 promotes healing-associated angiogenesis, research also demonstrates it can inhibit tumor-promoting effects of VEGF signaling via the MAPK pathway in melanoma cell lines, suggesting context-dependent modulation of vascular growth that may preferentially support physiological tissue repair over pathological neovascularization

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The day before the assay, Seahorse probe plates were prepared by adding 200 l distilled water, and calibration buffer was added to a 50 ml Falcon tube

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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

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