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Besides, caffeic acid and chlorogenic acid (caffeoylquinic acids) are two other classical phenolic acids widely found in natural plants, both of which are the most vital active substances in coffee [168]

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In our vaccine design, this allowed us to exploit the capacity of MVA to robustly prime CD4+ and CD8+ T cells 31 , a key requirement for providing immunologically nave elephant calves with an early and effective cellular immune response against primary EEHV infection

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The 26.5% TSAR in this study compares favourably with PRP studies, which typically report more modest improvements