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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (under the brand name Ozempic), chronic weight management in adults (as Wegovy), and weight management in pediatric patients aged 12 and older with obesity (also as Wegovy)
For this, we engineered a roGFP2-DsbA fusion construct and expressed it in the cytosol of the glr grx 1 grx 2 yeast cells, following the exogenous application of GSSG concentrations between 1.5-100 M
Med 9 , 2429 (2020)
From that program, two distinct peptides emerged the linear MC1R-preferential analog that became afamelanotide, and the cyclic broad-spectrum analog that became Melanotan 2
It also increases inflammation around the follicle, potentially damaging the dermal papilla cells that drive new hair growth
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