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Watch for anxiety and depression Research on GLP-1 medications and mood is still evolving, but some users report increased anxiety or low mood after discontinuation

Understanding Tirzepatide and Injection Site Reactions Tirzepatide is a dual-acting medication known as a GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist

If you are starting tirzepatide and suspect your GLP-1 related fatigue is excessive, consider whether suboptimal thyroid levels might be compounding the effect

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Consult your doctor or pharmacist for advice specific to your medications