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CJC-1295 without DAC (also called Modified GRF 1-29) has a half-life of approximately 30 minutes, while CJC-1295 with DAC binds to serum albumin via a maleimide linker and extends the half-life to roughly 68 days, allowing weekly rather than daily dosing in research models
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Other recently suggested Nrf2 activators, such as the cell-permeable alkylating agent, dimethyl itaconate (Mills et al
This protective effect is mediated through the upregulation of Nrf2 expression (51)
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Hepatic glutathione and glutathione S-conjugate transport mechanisms
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