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The study found that FOXO4 localizes predominantly in the cytoplasm of Leydig cells in young mice but translocates to the nucleus in aged animals the same FOXO4-p53 sequestration pattern seen in other senescent cell types

These trained-like features may enhance immune activation or induce tolerance, ultimately influencing clinical manifestations

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Individually, TB-500 has long been advanced by researchers for its potential positive action following myocardial infarction