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We covered the full landscape of semaglutide alternatives in a separate guide

Choline, inositol, and methionine are studied for their roles in hepatic phosphatidylcholine production (required for VLDL export of fat from the liver), methylation cycle function, and one-carbon metabolism pathways central to NAFLD and metabolic syndrome research

Treatment often involves dietary changes or vitamin B12 supplements

Emerging evidence underscores the necessity of moving beyond organ-specific approaches toward integrated therapeutic strategies (160, 161, 184, 185), and pharmacotherapies with pleiotropic benefits, including GLP-1RAs and SGLT2i (137139), show promise in simultaneously targeting muscle and vascular health

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