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Over the past decade, however, researchers are discovering that environmental factors like radiation, pollution, heavy metals and chemicals in the soil and water may be even more responsible for the increase in oxidative stress and chronic diseases
Riess H
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Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration
Muthusamy et al
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