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Indeed, GLP-1-expressing NTS neurons project to the lPBN [84, 85], and administration of exendin-4 into this brain region, where it has direct excitatory effects [85], robustly reduces food intake [84,85,86] and increases the expression of CGRP [85]
[54][55] In addition GLP-1 slows the rate of gastric emptying, which is often paradoxically accelerated in patients with diabetes
She is an endocrinologist and professor at the Yale School of Medicine
In a key clinical trial supporting the approval of teplizumab, participants taking the medication had a median time to a diagnosis of type 1 diabetes of 48 months compared to a median 24 months in those randomized to placebo
Understanding its clearance timeline is important when switching medications or preparing for surgery
10.1016/j.mce.2010.04.022 13 FaberR.ZanderM.PenaA.MichelsenM
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