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In the sea urchin, Paracentrotus lividus , exposed to starvation, lower amino acid excretion and poor gonad growth was reported to be associated with protein breakdown 14
If a patient becomes pregnant while receiving NAD+, the treatment would be discontinued unless there were extraordinary circumstances and a careful risk-benefit assessment by the healthcare provider
eLife 10, e65836
Even more serious is that B12 deficiency can disturb red blood cell formation and elevate homocysteine levels, which negatively impacts neurological and cardiovascular health, in addition to posing risks during pregnancy
