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Effect of subcutaneous Tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: the SURPASS-5 Randomized Clinical Trial

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Semaglutide activates the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the hypothalamic arcuate nucleus, the area postrema, the nucleus tractus solitarius, and vagal afferent neurons

Several factors contribute to this improvement

MOTS-c is not simply released from the mitochondria and degraded locally