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10.1002/ajhb.1310050603 58 HermansenK.BengtsenM.KjrM.VestergaardP.JrgensenJ
The FDA has approved Dupixent to treat the following nine conditions: Moderate to severe eczema: Approved for moderate to severe chronic atopic dermatitis Asthma: Approved as an add-on maintenance treatment for uncontrolled moderate-to-severe eosinophilic or oral steroid-dependent asthma Chronic obstructive pulmonary disease (COPD): Approved as an additional treatment for inadequately controlled COPD with high blood eosinophils Chronic rhinosinusitis with nasal polyps (CRSwNP) : Approved as an add-on maintenance treatment for uncontrolled nasal polyps Eosinophilic esophagitis (EOE): Approved to treat an inflamed esophagus caused by too many white blood cells Chronic spontaneous urticaria (CSU): Approved for treatment of hives not controlled by H1 antihistamines Bullous pemphigoid (BP): Approved to treat a skin condition that causes itchy, fluid-filled blisters Prurigo nodularis (PN): Approved to treat a skin condition that causes severe itching Allergic fungal rhinosinusitis (AFRS): Approved to treat some nasal symptoms and inflammation Dupixent changes how your immune system works, with the goal of preventing your body from reacting to substances that are not an actual threat
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On top of its important role as the powerhouse of the cell, these organelles are also essential regulators of cellular metabolism, redox state, intracellular calcium signaling, and programmed cell death mechanisms [12,13,14,15]
However, its native antioxidant defenses are insufficient to neutralize reactive oxygen species (ROS) in obesogenic microenvironments, and its inability to persistently colonize the inflamed gut limits therapeutic utility 14
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