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Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohns disease
On the other hand, oral replacement may improve adherence for patients who prefer oral medication to injections
The advantage of glutathione cream is the high safety profile it has, in comparison to creams such as hydroquinone & cysteamine
Understanding who stands to benefit the most helps allocate this tool where it provides the greatest value
Other oral are in FDA review and could hit the market in 2024
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