glucagon receptor retatrutide Scott Isaacs on X: "#retatrutide is a novel triple agonist peptide at the receptor, GIP receptor, and GLP-1 receptor. 22-24% weight loss at 48 weeks with a similar tolerability profile to # Retatrutide – 24mg – Prime

Excess loading can compress the spine and increase stress on already vulnerable hips and knees

Stacked Protocol (Cagrilintide + Smglutd) Dose: 0.6 2.4 mg Cagrilintide + 0.25 2.4 mg Smglutd (= 2496 clicks) Duration: 12 20 weeks Frequency: Once weekly, co-administered Cycle Interval: 4 6 weeks off before repeating Goal / Description: Dual amylin and GLP-1 receptor activation studied for enhanced metabolic and weight outcomes

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Nguyen said both the enrollment and prescription growth greatly exceeded their initial goal of a 10% increase in prescriptions in 2024

After 48 weeks, patients lost an average of 24.2% or 58 lb, compared to just 2.1% in the placebo group

Working with a provider lets you adjust as you go