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Stimulants cause tolerance development, meaning increasing doses are needed for the same effect

For research interpretation, the most useful angiogenesis data are those that connect multiple levels of evidence: endothelial cell behavior in vitro, VEGFR2 marker changes, functional tube formation, and tissue-level vascular outcomes in a selected preclinical model

Authors reported small statistically significant differences in weekly weight loss at the 1 mg dose with a non-linear dose response, but the abstract data has not been published in full peer-reviewed form

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